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It belongs to a group of drugs known as tricyclic antidepressants.
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People who start taking an antidepressant sometimes may initially have increased thoughts of suicide.
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Caution should be exercised when imipramine is used with agents that lower blood pressure. An overdose of Tofranil (Imipramine) can be fatal. If Tofranil is taken with certain other drugs, the effects of either could be increased, decreased, or altered.
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Be especially observant at the beginning of treatment or whenever there is a change in dose.
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Tofranil comes with an extra patient information sheet called a Medication Guide.
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